Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | DBH | P09172 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | TYMS | P04818 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139576 | 0.83 | DBH (0.45) | HDAC4HDAC2HDAC8DBHHDAC6 | |
| SCHEMBL29568960 | 0.78 | MAOA (0.58) | ALOX15TDP1TYMSMAOAMAPT | |
| SCHEMBL382951 | 0.78 | MAOA (0.58) | ALOX15TDP1TYMSMAOAMAPT | |
| SCHEMBL8693513 | 0.78 | MAOA (0.53) | DBHALOX15TDP1MAOAMAPT | |
| SCHEMBL31548711 | 0.77 | TDP1 (0.60) | ALOX15TDP1TYMSMAOAMAPT | |
| SCHEMBL2087097 | 0.77 | TDP1 (0.60) | ALOX15TDP1TYMSMAOAMAPT | |
| SCHEMBL21101011 | 0.75 | ALOX15 (0.41) | HDAC4HDAC2HDAC8DBHHDAC6 | |
| SCHEMBL9751985 | 0.73 | ELANE (0.55) | ALOX15TDP1MAOAMAPTHPGD | |
| SCHEMBL166198 | 0.71 | ALOX15 (0.52) | ALOX15TDP1TYMSHPGDALDH1A1 | |
| SCHEMBL308375 | 0.71 | TDP1 (0.52) | HDAC4HDAC2HDAC8HDAC6ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828483-B1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | LEPETIT SPA (IT) | 2003-01-29 | — | — | EP | disclosed |
| US-5990160-A | Use of tropolone derivatives as inhibitors of the enzyme inositol monophosphatase | GRUPPO LEPETIT, SPA (IT) | 1999-11-23 | — | — | US | disclosed |
| EP-0828483-A1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | GRUPPO LEPETIT S.p.A. (IT) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037197-A1 | USE OF TROPOLONE DERIVATIVES AS INHIBITORS OF THE ENZYME INOSITOL MONOPHOSPHATASE | GRUPPO LEPETIT S.P.A. (IT) | 1996-11-28 | — | — | WO | disclosed |