Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.46 |
| ▸ | ITGAV | P06756 | 7/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739452 | 0.82 | SUCNR1 (0.49) | SUCNR1NAMPTITGB3ITGA2BITGAV | |
| SCHEMBL739456 | 0.82 | SUCNR1 (0.49) | SUCNR1NAMPTITGB3ITGA2BITGAV | |
| SCHEMBL7143262 | 0.79 | PRMT5 (0.47) | ITGB3ITGA2BPRMT5WDR77ITGA2 | |
| SCHEMBL7145882 | 0.78 | SUCNR1 (0.69) | SUCNR1ITGB3ITGA2BITGAVGPR132 | |
| SCHEMBL6777398 | 0.77 | SUCNR1 (0.53) | SUCNR1ITGB3ITGA2BITGAVGPR132 | |
| SCHEMBL7138718 | 0.76 | SUCNR1 (0.49) | SUCNR1ITGB3ITGA2BITGAVITGA2 | |
| SCHEMBL6780209 | 0.76 | ITGB3 (0.55) | SUCNR1ITGB3ITGA2BITGAV | |
| SCHEMBL29391928 | 0.76 | ITGB3 (0.55) | SUCNR1ITGB3ITGA2BITGAV | |
| SCHEMBL6778483 | 0.76 | SUCNR1 (0.53) | SUCNR1ITGB3ITGA2BITGAV | |
| SCHEMBL3369186 | 0.74 | SUCNR1 (0.50) | SUCNR1ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928790-B1 | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2003-03-05 | — | — | EP | disclosed |
| US-6344562-B1 | ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2002-02-05 | — | — | US | disclosed |
| US-20020010316-A1 | Thiazole derivatives | ALIG LEO (CH) | 2002-01-24 | — | — | US | disclosed |
| US-6320054-B1 | INHIBIT BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES F CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS. | HOFFMAN-LA ROCHE INC. | 2001-11-20 | — | — | US | disclosed |
| US-6100282-A | Thiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0928790-A1 | Thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010316-A1 | Thiazole derivatives | VCAM1, SOST, TGFB1 | SUCNR1 704/4885NAMPT 809/4885ITGB3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.