Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7195631 | 1.00 | ADRA2C (0.30) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| Hydrochloric Acid SCHEMBL7136664 | 0.81 | NOS1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL7138513 | 0.80 | NOS1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL7142851 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7189674 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7137095 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL7777847 | 0.71 | NOS1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL7779196 | 0.71 | NOS1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL7779191 | 0.71 | NOS1 (0.33) | — | |
| SCHEMBL7143983 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882072-B1 | ANIONIC PHOTOCATALYST | DSM NV (NL) | 2000-11-08 | — | — | EP | claimed |
| EP-1047702-B1 | BIS(TETRAHYYDRO-INDENYL) METALLOCENES AS OLEFIN-POLYMERIZATION- CATALYST | BASELL POLYOLEFINE GMBH (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-1047702-A1 | BIS(TETRAHYYDRO-INDENYL) METALLOCENES AS OLEFIN-POLYMERIZATION- CATALYST | Montell Technology Company bv (NL) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000029416-A1 | BIS(TETRAHYDRO-INDENYL) METALLOCENES AS OLEFIN-POLYMERISATION-CATALYST | MONTELL TECHNOLOGY COMPANY B.V. (NL) | 2000-05-25 | — | — | WO | disclosed |