Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7777847 | 1.00 | NOS1 (0.33) | NOS1NOS2LMNATP53GAA | |
| Hydrochloric Acid SCHEMBL7779191 | 1.00 | NOS1 (0.33) | NOS1NOS2LMNATP53GAA | |
| Hydrochloric Acid SCHEMBL18663191 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL7142200 | 0.74 | NOS1 (0.31) | NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7143978 | 0.71 | ADRA2C (0.30) | — | |
| Hydrochloric Acid SCHEMBL7195631 | 0.71 | ADRA2C (0.30) | — | |
| Hydrochloric Acid SCHEMBL7772786 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL7777100 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL7780276 | 0.69 | — | — | |
| SCHEMBL7143983 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780395-B1 | Catalysts for the polymerization of alpha-olefins | ENICHEM SPA (IT) | 2001-08-29 | — | — | EP | disclosed |
| US-5917072-A | CYCLOPENTADIENYL ZIRCONIUM COMPOUNDS | ENICHEM S.P.A. (IT) | 1999-06-29 | — | — | US | disclosed |
| EP-0780395-A1 | Catalysts for the polymerization of alpha-olefins | ENICHEM S.p.A. (IT) | 1997-06-25 | — | — | EP | disclosed |