SCHEMBL7144493

SCHEMBL7144493

N[C@@H](CC1CCCCC1)C(=O)NCCc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.61
MMP3 P08254 11/20 0.57
MMP2 P08253 10/20 0.57
MMP1 P03956 8/20 0.57
NPC1 O15118 2/20 0.54
RAB9A P51151 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
TP53 P04637 1/20 0.54
EPHX1 P07099 1/20 0.54
TSHR P16473 1/20 0.54
TAAR1 Q96RJ0 3/20 0.51
ALDH1A1 P00352 2/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7358712 1.00 EPHX2 (0.61) EPHX2MMP3MMP2MMP1NPC1
SCHEMBL13073340 1.00 EPHX2 (0.61) EPHX2MMP3MMP2MMP1NPC1
SCHEMBL7353859 0.86 METAP2 (0.65) EPHX2MMP3MMP2MMP1NPC1
SCHEMBL4715141 0.85 EPHX2 (0.63) EPHX2MMP3MMP2MMP1NPC1
Hydrochloric Acid SCHEMBL7361806 0.85 METAP2 (0.63) EPHX2MMP3MMP2MMP1
SCHEMBL8362468 0.80 MMP3 (0.49) EPHX2MMP3MMP2MMP1
SCHEMBL7355387 0.79 METAP2 (0.62) EPHX2MMP3MMP2MMP1EPHX1
SCHEMBL5528697 0.79 CTSK (0.57) EPHX2MMP3MMP2MMP1NPC1
Hydrochloric Acid SCHEMBL7354348 0.78 METAP2 (0.61) EPHX2MMP3MMP2MMP1EPHX1
SCHEMBL4715413 0.78 MMP3 (0.54) EPHX2MMP3MMP2MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832100-A4 NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE AFFYMAX TECH NV (AN) 1998-09-02 EP claimed
EP-0832100-A1 NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE AFFYMAX TECHNOLOGIES N.V. (AN) 1998-04-01 EP claimed
WO-1996040204-A1 NOVEL INHIBITORS OF COLLAGENASE-1 AND STROMELYSIN-I METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE AFFYMAX TECHNOLOGIES, N.V. (AN) 1996-12-19 WO claimed
WO-1996040738-A1 NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE AFFYMAX TECHNOLOGIES, N.V. (AN) 1996-12-19 WO claimed
US-6552223-B1 Metalloproteinase enzyme inhibitors ASTRAZENECA AB (SE) 2003-04-22 US disclosed
US-6307101-B1 AMIDES SUBSTITUTED WITH MERCAPTOALCOHOL OR MERCAPTOKETONE GROUPS CAMPBELL DAVID A (US) 2001-10-23 US disclosed
EP-1109777-A1 N-HYDROXYACYLAMINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AstraZeneca AB (SE) 2001-06-27 EP disclosed
EP-0832100-B1 NOVEL INHIBITORS OF METALLOPROTEASES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AFFYMAX TECH NV (AN) 2000-04-05 EP disclosed
WO-2000012467-A1 N-HYDROXYACYLAMINO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRAZENECA AB (SE) 2000-03-09 WO disclosed
US-5929278-A Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use AFFYMAX TECHNOLOGIES N.V. (GB) 1999-07-27 US disclosed
US-5840698-A ENZYME INHIBITORS OF MERCAPTOKETONES AND MERCAPTOALCOHOLS FOR CONTROLLING DISEASES OF TISSUE BREAKDOWN, SKIN DISORDERS, ANTIINFLAMMATORY AGENTS OR ANTITUMOR AGENTS AFFYMAX TECHNOLOGIES N.V. (GB) 1998-11-24 US disclosed
US-5831004-A Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use AFFYMAX TECHNOLOGIES N.V. (GB) 1998-11-03 US disclosed
EP-0489577-B1 Peptidyl derivatives CELLTECH LTD (GB) 1995-03-22 EP disclosed
EP-0633886-A1 PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES PHARMACIA & UPJOHN COMPANY (US) 1995-01-18 EP disclosed
EP-0605682-A1 PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS CELLTECH THERAPEUTICS LIMITED (GB) 1994-07-13 EP disclosed
US-5300501-A Metalloproteinase inhibitors CELLTECH LIMITED (GB) 1994-04-05 US disclosed
WO-1993024449-A1 PEPTIDYL DERIVATIVES AND THEIR USE AS METALLOPROTEINASES INHIBITORS CELLTECH LIMITED (GB) 1993-12-09 WO disclosed
WO-1993020078-A1 PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES THE UPJOHN COMPANY (US) 1993-10-14 WO disclosed
WO-1992009565-A1 PEPTIDYL DERIVATIVES CELLTECH LIMITED (GB) 1992-06-11 WO disclosed
EP-0489577-A1 Peptidyl derivatives CELLTECH LIMITED (GB) 1992-06-10 EP disclosed