Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 11/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548267 | 0.84 | KDM4E (0.41) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL8550370 | 0.84 | KDM4E (0.41) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL8197371 | 0.83 | NPC1 (0.49) | KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL8180841 | 0.82 | HTR1F (0.44) | KMT2AGAAALDH1A1MAPTMAPK1 | |
| SCHEMBL7145980 | 0.81 | HTR1F (0.43) | KMT2AGAAALDH1A1MAPTMAPK1 | |
| SCHEMBL7147572 | 0.81 | MAPT (0.43) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL7140235 | 0.78 | ALDH1A1 (0.41) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL7141711 | 0.75 | SMN1; SMN2 (0.45) | KMT2AKDM4EGAAALDH1A1MAPT | |
| SCHEMBL7146842 | 0.74 | BRD4 (0.47) | GAAMAPTSMN1; SMN2HTT | |
| SCHEMBL7145107 | 0.72 | MAPT (0.43) | KMT2AKDM4EGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768301-B1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | LILLY CO ELI (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6126932-A | INSOLUBLE POLYMER BEARING PENDANT SIDE CHAINS, SAID SIDE CHAINS EACH TERMINATING WITH THE 1-(3-(1-PYRROLIDINYL)-PROPYL)-3-ETHYLCARBODIIMIDE MOIETY. | ELI LILLY AND COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0994109-A2 | 1-(3-(1-Pyrrolidinyl)propyl)-3-ethylcarbodiimide and a solid phase coupling agent | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| US-5998630-A | A 1-(3-(1-PYRROLIDINYL)PROPY)-3-ETHYLCARBODIIMIDE | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0768301-A1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |