Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931396 | 0.94 | BRD4 (0.48) | BRD4HTR6ADRA2AADRA2BADRA2C | |
| SCHEMBL8553359 | 0.84 | HIF1A (0.42) | HTR6MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL8549554 | 0.84 | HTR6 (0.42) | BRD4HTR6HTR7HTR2BMAPT | |
| SCHEMBL8180841 | 0.77 | HTR1F (0.44) | HTR6MAPTGAASMN1; SMN2 | |
| SCHEMBL7145980 | 0.74 | HTR1F (0.43) | EPHB2MAPTGAASMN1; SMN2 | |
| SCHEMBL7145054 | 0.74 | KMT2A (0.41) | MAPTGAAHTTSMN1; SMN2 | |
| SCHEMBL7138773 | 0.73 | IMPDH2 (0.45) | BRD4HTR6MAPT | |
| SCHEMBL7141353 | 0.73 | HTR1F (0.36) | HTR6ADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL8197371 | 0.71 | NPC1 (0.49) | SMN1; SMN2 | |
| SCHEMBL7144303 | 0.66 | BRD4 (0.43) | BRD4HTR6ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768301-B1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | LILLY CO ELI (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6126932-A | INSOLUBLE POLYMER BEARING PENDANT SIDE CHAINS, SAID SIDE CHAINS EACH TERMINATING WITH THE 1-(3-(1-PYRROLIDINYL)-PROPYL)-3-ETHYLCARBODIIMIDE MOIETY. | ELI LILLY AND COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0994109-A2 | 1-(3-(1-Pyrrolidinyl)propyl)-3-ethylcarbodiimide and a solid phase coupling agent | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| EP-0768301-A1 | N-(2-substituted-3-(2-aminoethyl)-1H-indol-5-yl)-amides as new 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1997-04-16 | — | — | EP | disclosed |