Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7140698 | 0.81 | SMN1; SMN2 (0.42) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7143137 | 0.75 | L3MBTL1 (0.45) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7175661 | 0.70 | MAPK1 (0.40) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14430566 | 0.70 | MAPK1 (0.39) | MAPK1SMN1; SMN2 | |
| SCHEMBL6987999 | 0.65 | MAPK1 (0.48) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL6991414 | 0.64 | HRH1 (0.46) | — | |
| SCHEMBL9258828 | 0.61 | L3MBTL1 (0.43) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7141281 | 0.60 | MAPK1 (0.44) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7142067 | 0.60 | MAPK1 (0.64) | MAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8709456 | 0.60 | MAPK1 (0.72) | MAPK1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588859-B1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |
| US-5461050-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-24 | — | — | US | disclosed |
| EP-0588859-A1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022553-A1 | IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518434-A1 | Imidazo(1,2-a)(pyrrolo, thieno or furano)(3,2-d)azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |