Naphthalene

Naphthalene

SCHEMBL7145629

O=S(=O)(O)O.[NaH].c1ccc2ccccc2c1

nearest known ligand 0.53

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.53
CYP2A6 P11509 1/20 0.53
TSHR P16473 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
LMNA P02545 2/20 0.42
KDM4E B2RXH2 3/20 0.41
CA5A P35218 1/20 0.40
CA5B Q9Y2D0 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
CA1 P00915 4/20 0.39
CA2 P00918 4/20 0.39
CA9 Q16790 3/20 0.39
MAPT P10636 2/20 0.39
HPGD P15428 1/20 0.39
CYP1A2 P05177 1/20 0.39
F2 P00734 1/20 0.39
PRSS1 P07477 1/20 0.39
PRSS2 P07478 1/20 0.39
PRSS3 P35030 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL28414009 0.97 ALOX12 (0.50) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL28674544 0.97 ALOX12 (0.57) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL2678900 0.97 ALOX12 (0.57) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL29361795 0.97 ALOX12 (0.57) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL5574575 0.97 ALOX12 (0.57) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL672294 0.97 ALOX12 (0.57) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL35778 0.94 ALOX12 (0.47) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL27964063 0.94 ALOX12 (0.47) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL28983768 0.93 ALOX12 (0.53) ALOX12CYP2A6TSHRSMN1; SMN2LMNA
Naphthalene SCHEMBL8773082 0.93 ALOX12 (0.53) ALOX12CYP2A6TSHRSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11414352-B2 Method for making a lightweight gypsum composition with internally generated foam and products made from same UNITED STATES GYPSUM COMPANY (US) 2022-08-16 US claimed
US-20030150068-A1 Dye-accelerant composition and process for using same JUNG JAMES (US) 2003-08-14 US claimed
US-20030005528-A1 Dye-accelerant composition and process for using same SILLA AMERICA, INC. 2003-01-09 US claimed
WO-2002092905-A1 DYE-ACCELERANT COMPOSITION AND PROCESS FOR USING SAME JUNG JAMES (US) 2002-11-21 WO claimed
US-5308734-A Toner processes XEROX CORPORATION (US) 1994-05-03 US claimed
EP-3882702-B1 FLUORESCENT WHITE TONERS AND RELATED METHODS XEROX CORP (US) 2026-01-28 EP disclosed
EP-3882703-B1 FLUORESCENT METALLIC TONERS AND RELATED METHODS XEROX CORP (US) 2025-05-07 EP disclosed
US-20250064145-A1 Bathrobe With Excellent Heat Retention and Washing Durability BIZLINK CO.,LTD (KR) 2025-02-27 US disclosed
US-12173191-B2 Body paint using toner particles XEROX CORPORATION (US) 2024-12-24 US disclosed
US-12001167-B2 High visibility fluorescent yellow toner and toner process XEROX CORPORATION (US) 2024-06-04 US disclosed
EP-3518042-B1 SECURITY TONER AND PROCESS OF USING THEREOF XEROX CORP (US) 2023-05-24 EP disclosed
CN-109790077-B Method for preparing lightweight gypsum compositions with internally generated foam and products prepared therefrom 美国石膏公司 2022-08-23 CN disclosed
US-5494611-A AQUEOUS COMPOSITION CONTAINING NONIONIC AMIDE SURFACTANT, ANIONIC SULFONATE OR SULFATE SURFACTANT, TERPENE; REMOVES DIRT AND GREASE WITHOUT STRIPPING WAX AND PAINT ARMOR ALL PRODUCTS CORPORATION (US) 1996-02-27 US disclosed
US-5422227-A Condensation polymers containing ionic groups; toners for electrography TOYO BOSEKI KABUSHIKI KAISHA (JP) 1995-06-06 US disclosed
WO-1995014753-A1 DUAL-PURPOSE CLEANING COMPOSITION FOR PAINTED AND WAXED SURFACES ARMOR ALL PRODUCTS CORPORATION (US) 1995-06-01 WO disclosed
US-5352521-A An ionic addition-condensation copolymers has narrow molecular weight distribution TOYO BOSEKI KABUSHIKI KAISHA (JP) 1994-10-04 US disclosed
US-5344673-A Particle size, polyesters TOYO BOSEKI KABUSHIKI KAISHA (JP) 1994-09-06 US disclosed
EP-0602871-A1 Toner processes XEROX CORPORATION (US) 1994-06-22 EP disclosed
US-5308734-A Toner processes XEROX CORPORATION (US) 1994-05-03 US disclosed
US-4926944-A HYDRAULIC CEMENT, WATER AND LIGNIN CROSSLINKED WITH FORMALDE-HYDE, EPICHLOROHYDRIN, ALLKOXYLATED WITH ETHYLENE, PROPYLENE OR BUTYLENE OXIDE WESTVACO CORPORATION (US) 1990-05-22 US disclosed