Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043078 | 0.89 | JAK1 (0.60) | PDE4DKDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL2257907 | 0.87 | MAPT (0.49) | PDE4DKDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL7146898 | 0.87 | KDM4E (0.51) | PDE4DKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2250839 | 0.87 | PDE4D (0.64) | PDE4DKDM4EPDE10AJAK1HSP90AB1 | |
| SCHEMBL7143153 | 0.85 | PDE4D (0.46) | PDE4DKDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL7145674 | 0.84 | PDE10A (0.50) | PDE4DHPGDPDE10AJAK1HSP90AB1 | |
| SCHEMBL6875680 | 0.80 | PDE10A (0.44) | PDE4DPDE10AJAK1HSP90AB1TUBB4A | |
| SCHEMBL7043841 | 0.79 | MAPT (0.51) | PDE4DKDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL7143142 | 0.78 | JAK2 (0.48) | PDE4DPDE10AHSP90AB1MAPT | |
| SCHEMBL7146570 | 0.78 | PDE4D (0.48) | PDE4DSMN1; SMN2PDE10AJAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514989-B1 | Has a good affinity to the adenosine receptor and can therefore be used for the treatment or protection of diseases mediated by this receptor | HOFFMANN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |