Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021656 | 0.97 | DRD2 (0.39) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL7139807 | 0.93 | DRD2 (0.38) | DRD2DRD3DRD4ALDH1A1MAPK9 | |
| SCHEMBL6022189 | 0.87 | CYP3A4 (0.36) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL6021776 | 0.84 | MAPK9 (0.33) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL3480051 | 0.83 | MAPK9 (0.54) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL4192955 | 0.81 | MAPK9 (0.52) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL3479821 | 0.80 | MAPK9 (0.54) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL4967650 | 0.80 | MAPK9 (0.53) | TMEM97SIGMAR1DRD2DRD3DRD4 | |
| SCHEMBL7139566 | 0.78 | KDM4E (0.42) | KMT2AMEN1RAB9AALDH1A1MAPK9 | |
| SCHEMBL3479709 | 0.78 | MAPK9 (0.54) | TMEM97SIGMAR1DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322642-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | Applied Research Systems ARS Holding N.V. (AN) | 2003-07-02 | — | — | EP | claimed |
| WO-2002026733-A2 | sHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES BEARING BOTH LIPOPHILIC AND IONISABLE MOIETIES AS INHIBITORS OF PROTEIN JUNKINASES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2002-04-04 | — | — | WO | claimed |