Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 4/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP7 | P09237 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257396 | 0.87 | PDK1 (0.51) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL6473595 | 0.82 | HTT (0.67) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL5141182 | 0.82 | HTT (0.60) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL26964038 | 0.81 | PDK1 (0.54) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL2419015 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL5115243 | 0.80 | HTT (0.59) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL5077234 | 0.80 | HTT (0.59) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL14313090 | 0.80 | HTT (0.59) | SMN1; SMN2NPC1RAB9AHTTMMP9 | |
| SCHEMBL7276728 | 0.80 | PRCP (0.66) | SMN1; SMN2RAB9APRCPKMT2ANPSR1 | |
| SCHEMBL895978 | 0.80 | HTT (0.77) | SMN1; SMN2NPC1RAB9AHTTMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368343-A1 | 1-(2-METHOXYBENZYL)-3-BENZHYDRYLPIPERAZINES AS TACHYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002055518-A1 | 1-(2-METHOXYBENZYL)-3-BENZHYDRYLPIPERAZINES AS TACHYKININ ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-07-18 | — | — | WO | disclosed |