Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247482 | 0.82 | SULT1A1 (0.42) | MEN1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL4246679 | 0.75 | PDE7A (0.44) | PDE4DPDE7API4KB | |
| SCHEMBL6454854 | 0.70 | NPC1 (0.48) | MEN1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL4250476 | 0.70 | PDE7A (0.50) | MEN1ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL6464643 | 0.66 | RAB9A (0.52) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL4252175 | 0.62 | PDE7A (0.52) | LMNACYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL14736582 | 0.61 | ALDH1A1 (0.50) | MEN1ALDH1A1LMNAMAPTHTT | |
| SCHEMBL849073 | 0.61 | MAPK8 (0.49) | MAPK8MAPK9JAK1JAK3 | |
| SCHEMBL19307821 | 0.60 | CA2 (0.70) | KMT2A | |
| SCHEMBL21162215 | 0.60 | MAPK8 (0.79) | MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348701-A1 | (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors | Warner-Lambert Company LLC (US) | 2003-10-01 | — | — | EP | disclosed |