Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6377672 | 0.93 | MAPT (0.44) | LMNACYP2C19MAPTTDP1L3MBTL1 | |
| SCHEMBL6377134 | 0.89 | CYP1A2 (0.46) | LMNACYP2C19CYP1A2MAPTMAPK1 | |
| SCHEMBL3876703 | 0.75 | MAPT (0.44) | MAPTTDP1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL16491623 | 0.73 | HTT (0.59) | LMNAMAPTTDP1L3MBTL1MAPK1 | |
| SCHEMBL23926355 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A3 | |
| SCHEMBL30118946 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A3 | |
| SCHEMBL3869852 | 0.71 | L3MBTL1 (0.49) | CYP2C19MAPTTDP1L3MBTL1MAPK1 | |
| SCHEMBL16415760 | 0.70 | MEN1 (0.52) | LMNAMAPTTDP1L3MBTL1MAPK1 | |
| SCHEMBL3943486 | 0.70 | L3MBTL1 (0.51) | MAPTTDP1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL11067263 | 0.70 | LTA4H (0.58) | MAPTTDP1L3MBTL1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599917-B1 | A squalene-synthesizing enzyme inhibitor, a cholesterol biosynthesis inhibitor and a triglyceride biosynthesis inhibitor | EISAI CO., LTD. (JP) | 2003-07-29 | — | — | US | disclosed |