Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9471237 | 0.84 | NPC1 (0.61) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL9133596 | 0.81 | ALDH1A1 (0.59) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL9159392 | 0.77 | ALDH1A1 (0.55) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL9134088 | 0.77 | ALDH1A1 (0.54) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL1609155 | 0.76 | NPC1 (1.00) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL9159221 | 0.73 | MEN1 (0.52) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A | |
| SCHEMBL29398039 | 0.72 | L3MBTL1 (0.63) | NPC1ALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL8828063 | 0.71 | RAB9A (0.49) | NPC1ALDH1A1RAB9AKMT2AGAA | |
| SCHEMBL28610800 | 0.70 | ALDH1A1 (0.77) | NPC1ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL876385 | 0.69 | MMP2 (0.59) | NPC1RPS6KA2ALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035848-B1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORP (US) | 2003-04-23 | — | — | EP | claimed |
| EP-1035848-B1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORP (US) | 2003-04-23 | — | — | EP | disclosed |