Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301058 | 0.90 | GRM4 (0.56) | GRM4BRAFMAPK14PTGS2ALDH1A1 | |
| SCHEMBL17477104 | 0.83 | GAA (0.50) | GRM4BRAFMAPK14ALDH1A1KMT2A | |
| SCHEMBL17619706 | 0.80 | PTGS2 (0.51) | BRAFMAPK14PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6098497 | 0.75 | GRM4 (0.44) | GRM4BRAFMAPK14PTGS2ALDH1A1 | |
| SCHEMBL5829487 | 0.75 | ALDH1A1 (0.51) | BRAFMAPK14PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12019071 | 0.74 | GAA (0.48) | GRM4PTGS2ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL17619710 | 0.74 | PTGS2 (0.54) | BRAFMAPK14PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL5341410 | 0.72 | RAB9A (0.50) | GRM4PTGS2ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7249032 | 0.72 | GRM4 (0.57) | GRM4ALDH1A1HPGDKDM4EMAPK1 | |
| Ammonia Solution, Strong SCHEMBL5256823 | 0.72 | MAPK13 (0.54) | BRAFMAPK14ALDH1A1MAPK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525059-B1 | Mitogen-activated protein kinases (MAP); | G. D. SEARLE & COMPANY | 2003-02-25 | — | — | US | disclosed |