Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | MELK | Q14680 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248577 | 0.87 | MAPK14 (0.52) | ALDH1A1KDM4ELMNATSHRMAPK1 | |
| SCHEMBL6337994 | 0.87 | MELK (0.51) | MAPK14CSNK1DMELKBRAFPTGS2 | |
| SCHEMBL7148386 | 0.75 | GRM4 (0.55) | ALDH1A1KDM4ELMNAMAPK1MAPK14 | |
| SCHEMBL1753041 | 0.73 | CSNK1D (0.60) | ALDH1A1KDM4ELMNATSHRMAPK1 | |
| SCHEMBL17619706 | 0.72 | PTGS2 (0.51) | ALDH1A1KDM4ELMNAMAPK14BRAF | |
| SCHEMBL5829519 | 0.72 | CYP17A1 (0.51) | ALDH1A1TSHRMAPK1MAPK14KMT2A | |
| SCHEMBL5463406 | 0.71 | ROCK2 (0.44) | ALDH1A1KDM4ELMNATSHRMAPK1 | |
| SCHEMBL7250809 | 0.69 | AKR1C3 (0.46) | ALDH1A1BRAFSMN1; SMN2KMT2AL3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL5740005 | 0.69 | ADRA2C (0.50) | KMT2A | |
| SCHEMBL28337260 | 0.68 | MELK (0.69) | ALDH1A1KDM4EMELKSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071198-B1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |