Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6280880 | 0.98 | JAK2 (0.49) | JAK2TYK2MAPK1P2RX7CES2 | |
| SCHEMBL3377623 | 0.83 | CES2 (0.47) | P2RX7CES2CES1POLBKMT2A | |
| SCHEMBL7143404 | 0.83 | CYP11B2 (0.50) | CES2CES1POLBLMNAKMT2A | |
| Bromide SCHEMBL6283092 | 0.82 | CYP11B2 (0.49) | POLBLMNAKMT2AMEN1MAPT | |
| SCHEMBL7147778 | 0.81 | TYK2 (0.50) | TYK2MAPK1CES2CES1ALDH1A1 | |
| Bromide SCHEMBL6280875 | 0.79 | TYK2 (0.49) | TYK2MAPK1CES2CES1ALDH1A1 | |
| SCHEMBL7840807 | 0.77 | RAB9A (0.47) | CES2CES1POLBLMNAKMT2A | |
| SCHEMBL7149331 | 0.77 | TSHR (0.50) | JAK2MAPK1POLBKMT2AMEN1 | |
| SCHEMBL3115655 | 0.76 | MEN1 (0.52) | JAK2TYK2CES2CES1LMNA | |
| Bromide SCHEMBL6284643 | 0.76 | TSHR (0.49) | JAK2MAPK1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620825-B1 | 1,3-Azole compound substituted by pyridyl; administering as antiasthmatic, antiinflammatory or antiallergen agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-16 | — | — | US | disclosed |
| US-6436966-B1 | Adenosine A3 receptor antagonists | TAKEDA CHEMICAL IND., LTD. (JP) | 2002-08-20 | — | — | US | disclosed |