Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236586 | 0.85 | TDP1 (0.54) | LMNASMN1; SMN2L3MBTL1POLBPKM | |
| SCHEMBL7372302 | 0.74 | SMN1; SMN2 (1.00) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL13055383 | 0.74 | LMNA (0.80) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL3811564 | 0.74 | L3MBTL1 (0.80) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL11085496 | 0.74 | LMNA (0.74) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL21987005 | 0.74 | LMNA (0.74) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL35211277 | 0.74 | LMNA (0.74) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL5797452 | 0.74 | LMNA (0.74) | LMNASMN1; SMN2L3MBTL1MAPTPOLB | |
| SCHEMBL30823376 | 0.73 | SMN1; SMN2 (0.97) | LMNASMN1; SMN2L3MBTL1MAPTHTT | |
| SCHEMBL25538805 | 0.73 | LMNA (0.79) | LMNASMN1; SMN2L3MBTL1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |