Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 13/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7151274 | 0.95 | PDK1 (0.55) | PDK1LMNATP53MAPTRXFP1 | |
| SCHEMBL7149325 | 0.90 | MAPT (0.53) | PDK1LMNATP53MAPTRXFP1 | |
| SCHEMBL7149774 | 0.89 | MAPT (0.50) | PDK1LMNATP53MAPTTHRB | |
| SCHEMBL7150971 | 0.88 | MAPT (0.52) | PDK1LMNATP53MAPTRXFP1 | |
| SCHEMBL7148785 | 0.87 | MAPT (0.47) | LMNATP53MAPTRXFP1MAPK1 | |
| SCHEMBL7149256 | 0.87 | MAPT (0.54) | PDK1LMNATP53MAPTTHRB | |
| SCHEMBL7151099 | 0.87 | MAPT (0.51) | PDK1LMNATP53MAPTRXFP1 | |
| SCHEMBL7153222 | 0.84 | PDK1 (0.53) | PDK1LMNATP53MAPTRXFP1 | |
| SCHEMBL7154367 | 0.84 | L3MBTL1 (0.55) | LMNATP53MAPTMAPK1L3MBTL1 | |
| SCHEMBL7149643 | 0.83 | PDK1 (0.50) | PDK1LMNATP53MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642263-B2 | Antitumor agents, sulfided benzothiazole derivative containing sulfonamide | ICONIX PHARMACEUTICALS INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030176474-A1 | Modulators of Rho C activity | ICONIX BIOSCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176474-A1 | Modulators of Rho C activity | RHOC, ARHGDIA, ROCK1 | PDK1 4188/4885LMNA 1481/4885TP53 4600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.