Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.69 |
| ▸ | PDE4A | P27815 | 11/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7149565 | 1.00 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8769594 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8769586 | 0.90 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7447179 | 0.84 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7447175 | 0.84 | PDE4B (0.74) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7309530 | 0.84 | PDE4D (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7394229 | 0.84 | PDE4D (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL1028427 | 0.82 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL30009845 | 0.82 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7406024 | 0.82 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | claimed |
| EP-0672031-B1 | CATECHOL DIETHERS AS SELECTIVE PDE IV INHIBITORS | PFIZER (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |