Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 2/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7150372 | 0.88 | HTR2A (0.47) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL10920498 | 0.78 | HTR2C (0.54) | HTR2AHTR7HTR1AKDM4EMEN1 | |
| SCHEMBL7142123 | 0.75 | HTR2A (0.59) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL7145886 | 0.73 | HTR2A (0.47) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL7140214 | 0.72 | HTR2A (0.61) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL6589098 | 0.68 | HTR1A (0.54) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL24279609 | 0.68 | HTR2A (0.57) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL23459131 | 0.66 | PLD2 (0.62) | HTR2AHTR7KCNH2DRD2HTR1A | |
| SCHEMBL10920489 | 0.66 | HTR2C (0.64) | HTR2AHTR7DRD2SLC6A4HTR1A | |
| SCHEMBL28839286 | 0.65 | HTR2A (0.48) | HTR2AHTR7KCNH2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808313-B1 | ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |