Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418028 | 0.81 | ALOX5 (0.49) | CTSDKMT2APOLBPKMPTPN1 | |
| SCHEMBL4753938 | 0.74 | KMT2A (0.65) | KMT2APOLBPKMPTPN1PTPN7 | |
| SCHEMBL4753906 | 0.72 | KMT2A (0.52) | KMT2APOLBPKMPTPN1PTPN7 | |
| SCHEMBL27153567 | 0.72 | POLB (0.40) | KMT2APOLBPKMPTPN1PTPN7 | |
| SCHEMBL4751567 | 0.72 | KMT2A (0.47) | KMT2APOLBPKMPTPN1PTPN7 | |
| SCHEMBL5368294 | 0.68 | POLB (0.47) | KMT2APOLBALOX5MEN1ALDH1A1 | |
| SCHEMBL744074 | 0.68 | CTSD (1.00) | CTSDKMT2APOLBPKML3MBTL1 | |
| SCHEMBL11627693 | 0.68 | KMT2A (0.56) | KMT2APOLBPKMPTPN1PTPN7 | |
| SCHEMBL5665309 | 0.68 | KMT2A (0.57) | CTSDKMT2APOLBPKMPTPN1 | |
| SCHEMBL11416152 | 0.68 | KMT2A (0.43) | KMT2APOLBPKMPTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337535-A2 | BENZODIAZEPINE DERIVATIVES AS GABA A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040487-A2 | BENZODIAZEPINE DERIVATIVES AS GABA A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |