Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6800007 | 0.89 | KMO (0.56) | KMOKDM4EKEAP1ALDH1A1GAA | |
| SCHEMBL8943468 | 0.85 | KMO (0.41) | KMOTSHRKDM4EKEAP1GAA | |
| SCHEMBL4287323 | 0.81 | TSHR (0.52) | TSHRALDH1A1GAAHPGDRAB9A | |
| SCHEMBL16719377 | 0.80 | NPC1 (0.59) | SMN1; SMN2NPC1GAARAB9A | |
| SCHEMBL1510035 | 0.77 | KMO (0.59) | KMODAOTSHRNAPRTKDM4E | |
| SCHEMBL1535844 | 0.74 | ALDH1A1 (0.38) | KMOKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL8471292 | 0.74 | ALOX5 (0.43) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL10469452 | 0.73 | TSHR (0.48) | DAOTSHRNAPRTNPC1RAB9A | |
| SCHEMBL8447343 | 0.73 | KMT2A (0.43) | TSHRKDM4ENPC1RAB9AEGFR | |
| SCHEMBL1451004 | 0.73 | ALDH1A1 (0.43) | KMOKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645960-B1 | Antiprotozoa agents for animal or human infections | GLAXO WELLCOME S.A. (ES) | 2003-11-11 | — | — | US | disclosed |
| EP-1228049-A1 | ANTIFUNGAL SORDARICIN DERIVATIVES | Glaxo Wellcome S.A. (ES) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001034583-A1 | ANTIFUNGAL SORDARICIN DERIVATIVES | GLAXO WELLCOME SA (ES) | 2001-05-17 | — | — | WO | disclosed |