Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | PPARA | Q07869 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | CDC42 | P60953 | 1/20 | 0.46 |
| ▸ | RAC1 | P63000 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10326014 | 0.83 | MTNR1B (0.42) | CYP1A2PTGS1TSHRMEN1KMT2A | |
| SCHEMBL10326015 | 0.83 | MTNR1B (0.42) | CYP1A2PTGS1TSHRMEN1KMT2A | |
| SCHEMBL28696899 | 0.78 | CYP1A2 (0.68) | PPARGPPARACYP1A2CYP2A6PTGS2 | |
| SCHEMBL20045393 | 0.76 | CYP1A2 (0.66) | PPARGPPARACYP1A2PTPN7MEN1 | |
| SCHEMBL2597632 | 0.76 | CYP1A2 (0.66) | PPARGPPARACYP1A2PTPN7MEN1 | |
| SCHEMBL43517 | 0.73 | RAB9A (0.54) | CYP1A2MEN1MAPTKMT2ARAB9A | |
| SCHEMBL29478375 | 0.73 | RAB9A (0.54) | CYP1A2MEN1MAPTKMT2ARAB9A | |
| SCHEMBL43518 | 0.73 | RAB9A (0.54) | CYP1A2MEN1MAPTKMT2ARAB9A | |
| SCHEMBL288854 | 0.73 | RAB9A (0.54) | CYP1A2MEN1MAPTKMT2ARAB9A | |
| SCHEMBL29350028 | 0.73 | RAB9A (0.54) | CYP1A2MEN1MAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728147-B1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH INC (US) | 2003-02-12 | — | — | EP | claimed |
| US-5846932-A | Receptor specific atrial natriuretic peptides | GENENTECH, INC. (US) | 1998-12-08 | — | — | US | claimed |
| US-5665704-A | VASODILATORS, HYPOTENSIVE AGENTS; METABOLIC STABILITY | GENENTECH, INC. (US) | 1997-09-09 | — | — | US | claimed |
| EP-0728147-A1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH, INC. (US) | 1996-08-28 | — | — | EP | claimed |
| WO-1995013296-A1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH, INC. (US) | 1995-05-18 | — | — | WO | claimed |
| US-6525022-B1 | Congestive heart failure, acute kidney failure and renal hypertension; amide bond residues AA7 and AA8is replaced with an amide isostere | GENENTECH, INC. | 2003-02-25 | — | — | US | disclosed |
| EP-0728147-B1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-5846932-A | Receptor specific atrial natriuretic peptides | GENENTECH, INC. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5665704-A | VASODILATORS, HYPOTENSIVE AGENTS; METABOLIC STABILITY | GENENTECH, INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0728147-A1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH, INC. (US) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013296-A1 | RECEPTOR SPECIFIC ATRIAL NATRIURETIC PEPTIDES | GENENTECH, INC. (US) | 1995-05-18 | — | — | WO | disclosed |