Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049712 | 0.89 | BCL2 (0.44) | CTSSCTSKBCL2NOTUMPTGS2 | |
| SCHEMBL982140 | 0.77 | GABRA1 (0.35) | GABRA1GABRB2 | |
| SCHEMBL5832593 | 0.75 | ALOX5 (0.31) | ALOX5 | |
| SCHEMBL196298 | 0.74 | CTSS (0.51) | CTSSCTSKBCL2HTR7 | |
| SCHEMBL30777855 | 0.74 | CTSS (0.51) | CTSSCTSKBCL2HTR7 | |
| SCHEMBL11035263 | 0.74 | RARB (0.44) | — | |
| SCHEMBL983255 | 0.74 | SREBF2 (0.33) | CTSK | |
| SCHEMBL2722296 | 0.74 | EGFR (0.38) | NOTUMGABRA1GABRB2 | |
| SCHEMBL25380703 | 0.73 | BCL2 (0.53) | CTSSCTSKBCL2NOTUMPTGS2 | |
| SCHEMBL24005570 | 0.72 | CTSS (0.50) | CTSSCTSKBCL2PTGS2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003502330-A | — | — | 2003-01-21 | — | — | JP | claimed |
| EP-1189905-A1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | Bristol-Myers Squibb Pharma Company (US) | 2002-03-27 | — | — | EP | claimed |
| WO-2000077001-A1 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-12-21 | — | — | WO | claimed |