SCHEMBL2722296

SCHEMBL2722296

CCc1ccc(-c2[c]cccc2CC)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.38
TP53 P04637 2/20 0.37
NOTUM Q6P988 1/20 0.37
ALDH1A1 P00352 1/20 0.34
UCHL1 P09936 1/20 0.34
GABRA1 P14867 2/20 0.33
GABRB2 P47870 2/20 0.33
CA2 P00918 1/20 0.33
TAOK1 Q7L7X3 1/20 0.33
TAOK3 Q9H2K8 1/20 0.33
CTSV O60911 1/20 0.33
CTSL P07711 1/20 0.33
NPC1 O15118 1/20 0.33
POLB P06746 1/20 0.33
GAA P10253 1/20 0.33
RAB9A P51151 1/20 0.33
METAP2 P50579 1/20 0.33
TAAR1 Q96RJ0 1/20 0.32
GALR1 P47211 1/20 0.32
NISCH Q9Y2I1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11035263 0.85 RARB (0.44) ALDH1A1CA2CTSVCTSLNISCH
SCHEMBL982140 0.85 GABRA1 (0.35) TP53GABRA1GABRB2MGLL
SCHEMBL8089782 0.81 TP53 (0.37) EGFRTP53NOTUMALDH1A1UCHL1
SCHEMBL15049712 0.81 BCL2 (0.44) TP53NOTUMGABRA1GABRB2NISCH
SCHEMBL8074244 0.80 FAAH (0.38) EGFRTP53NOTUMUCHL1NPC1
SCHEMBL11109664 0.78 MAPT (0.40) ALDH1A1CA2POLBGAARAB9A
SCHEMBL8089555 0.77 NPC1 (0.38) EGFRTP53CA2NPC1POLB
SCHEMBL8088888 0.76 ALDH1A1 (0.37) TP53ALDH1A1NPC1POLBGAA
SCHEMBL7151981 0.74 CTSS (0.38) NOTUMGABRA1GABRB2
SCHEMBL6928439 0.73 CYP2D6 (0.41) ALDH1A1GABRA1GABRB2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2632420-A1 GLUTAMINE DERIVATIVES AS DEODORANTS Givaudan SA (CH) 2013-09-04 EP disclosed
WO-2012056014-A1 GLUTAMINE DERIVATIVES AS DEODORANTS GIVAUDAN SA (CH) 2012-05-03 WO disclosed