Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 8/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092903 | 0.82 | POLB (0.60) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7148309 | 0.81 | MAPT (0.68) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7153529 | 0.80 | NPC1 (0.69) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7150779 | 0.78 | HTT (0.63) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1268314 | 0.78 | POLB (0.54) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5163049 | 0.77 | NAMPT (0.48) | NPC1RAB9AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL7154056 | 0.77 | ALDH1A1 (0.66) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5443184 | 0.75 | MAPT (0.57) | MAPTSMN1; SMN2ALDH1A1HPGDTP53 | |
| SCHEMBL6816361 | 0.75 | POLB (0.73) | POLBNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7088328 | 0.74 | MAPT (0.68) | NPC1RAB9AMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351938-A1 | PHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057236-A1 | PHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |