Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 12/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7151043 | 0.97 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7151763 | 0.94 | POLB (0.42) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7149221 | 0.90 | LMNA (0.47) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7147149 | 0.89 | MAPT (0.43) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7154989 | 0.87 | LMNA (0.48) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7153034 | 0.86 | MAPT (0.44) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7148116 | 0.86 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7151259 | 0.85 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2MAPTLMNATHRB | |
| SCHEMBL7149819 | 0.84 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MAPTLMNAPOLB | |
| SCHEMBL7149163 | 0.84 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPTLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6642263-B2 | Antitumor agents, sulfided benzothiazole derivative containing sulfonamide | ICONIX PHARMACEUTICALS INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030176474-A1 | Modulators of Rho C activity | ICONIX BIOSCIENCES, INC. | 2003-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176474-A1 | Modulators of Rho C activity | RHOC, ARHGDIA, ROCK1 | ALDH1A1 2919/4885SMN1; SMN2 3295/4885MAPT 3839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.