SCHEMBL7153255

SCHEMBL7153255

CC(=O)Nc1ccc([C@@H](O)CN)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.54
SMN1; SMN2 Q16637 3/20 0.52
HTT P42858 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
ALDH1A1 P00352 5/20 0.50
TSHR P16473 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
TAAR1 Q96RJ0 2/20 0.50
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA9 Q16790 2/20 0.50
HIF1A Q16665 2/20 0.50
HTR3A P46098 1/20 0.50
NFKB1 P19838 1/20 0.50
BRD4 O60885 1/20 0.50
NR1I2 O75469 1/20 0.50
MB P02144 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21483681 0.84 TAAR1 (0.52) HTTL3MBTL1ALDH1A1TSHRTDP1
SCHEMBL11548925 0.84 KIF11 (0.54) ALDH1A1TSHRTDP1MEN1KMT2A
SCHEMBL6535359 0.82 DHODH (0.54) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL6324850 0.82 DHODH (0.54) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL9193955 0.81 DHODH (0.53) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL6318456 0.81 TDP1 (0.58) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
Hydrochloric Acid SCHEMBL28029171 0.81 SMN1; SMN2 (0.50) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL7154500 0.80 ALDH1A1 (0.54) L3MBTL1ALDH1A1TSHRMEN1KMT2A
SCHEMBL6316512 0.79 DHODH (0.51) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1
SCHEMBL11112670 0.79 SMN1; SMN2 (0.61) DHODHSMN1; SMN2HTTL3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030143701-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. 2003-07-31 US disclosed
EP-0924194-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2003-05-14 EP disclosed
US-6528686-B1 Reacting primary amine and ketone functionalized derivatives; catalytically reducing DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2003-03-04 US disclosed
EP-0924193-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2003-02-19 EP disclosed
EP-0939134-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2002-09-11 EP disclosed
US-6114582-A DECYCLIZATION TO FORM A CHEMICAL INTERMEDIATE FOR PRODUCING AN ANTI-OBESITY AGENT AND ANTIDIABETIC AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-05 US disclosed
EP-0654534-B1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEM (JP) 2000-03-01 EP disclosed
EP-0939134-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-09-01 EP disclosed
EP-0924193-A1 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-06-23 EP disclosed
EP-0924194-A2 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1999-06-23 EP disclosed
US-5811293-A CULTURE PRODUCT AS CHEMICAL INTERMEDIATE FOR ANTI-OBESITY AGENT DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-22 US disclosed
US-5629200-A MICROORGANISM DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1997-05-13 US disclosed
EP-0654534-A2 Processes for producing optically active 2-amino-1-phenylethanol derivatives DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1995-05-24 EP disclosed