Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PCTP | Q9UKL6 | 3/20 | 0.41 |
| ▸ | STARD10 | Q9Y365 | 2/20 | 0.41 |
| ▸ | STARD7 | Q9NQZ5 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878627 | 0.87 | ADRA2B (0.52) | ADRA2BMAPTALDH1A1PCTPSTARD10 | |
| SCHEMBL715497 | 0.79 | MAPT (0.42) | CNR2MAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL715496 | 0.78 | ADRA2B (0.43) | ADRA2BMAPTPCTPSTARD10STARD7 | |
| SCHEMBL4884322 | 0.76 | CA1 (0.55) | ADRA2BEDNRALMNA | |
| SCHEMBL4662757 | 0.74 | CA9 (0.50) | CNR2NR3C1PGRLMNA | |
| SCHEMBL14018738 | 0.74 | LMNA (0.59) | ALDH1A1NPC1LMNAHTTSMN1; SMN2 | |
| SCHEMBL715945 | 0.73 | MAPT (0.51) | CNR2MAPTALDH1A1MAPK1HSD17B10 | |
| SCHEMBL714554 | 0.72 | ALDH1A1 (0.64) | MAPTALDH1A1HSD17B10LMNAHTT | |
| SCHEMBL14018681 | 0.69 | MAPT (0.53) | MAPTALDH1A1PCTPSTARD10STARD7 | |
| SCHEMBL15127571 | 0.68 | GAA (0.51) | MAPTALDH1A1HSD11B1EDNRALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | claimed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | claimed |
| US-20120052057-A9 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2012-03-01 | — | — | US | disclosed |
| US-20110150859-A1 | METHOD FOR SELECTING RESPONDERS TO BLOCKADE OF INTEGRIN RECEPTORS | BIOTIE THERAPIES CORPORATION (FI) | 2011-06-23 | — | — | US | disclosed |