Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.81 |
| ▸ | MMP13 | P45452 | 6/20 | 0.81 |
| ▸ | MMP2 | P08253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7111889 | 1.00 | ADAM17 (0.81) | ADAM17MMP13MMP2 | |
| SCHEMBL7111688 | 0.91 | ADAM17 (0.92) | ADAM17MMP13 | |
| SCHEMBL7113366 | 0.90 | ADAM17 (1.00) | ADAM17MMP13 | |
| SCHEMBL7111133 | 0.89 | ADAM17 (0.82) | ADAM17MMP13MMP2 | |
| SCHEMBL7111356 | 0.89 | ADAM17 (1.00) | ADAM17MMP13 | |
| SCHEMBL7111970 | 0.89 | ADAM17 (1.00) | ADAM17MMP13 | |
| SCHEMBL7106430 | 0.89 | ADAM17 (1.00) | ADAM17MMP13MMP2 | |
| SCHEMBL7107278 | 0.89 | ADAM17 (0.85) | ADAM17MMP13MMP2 | |
| SCHEMBL7111344 | 0.89 | ADAM17 (1.00) | ADAM17MMP13MMP2 | |
| Trifluoroacetic Acid SCHEMBL7111941 | 0.87 | ADAM17 (0.85) | ADAM17MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030087890-A1 | 1,2,-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha | BRISTOL-MYERS SQUIBB COMPANY, (FORMERLY D/B/A DUPONT PHARMACEUTICALS COMPANY) | 2003-05-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087890-A1 | 1,2,-Disubstituted cyclic inhibitors of matrix metalloproteases and TNF-alpha | MMP1, MMP8, MMP9 | ADAM17 19/4885MMP13 10/4885MMP2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.