Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656139 | 0.84 | ALDH1A1 (0.47) | OPRK1GRM5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1012743 | 0.84 | SLC6A2 (0.48) | OPRK1SLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL7464514 | 0.84 | SLC6A2 (0.48) | OPRK1SLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL7160342 | 0.81 | ALDH1A1 (0.35) | GRM5SLC6A2SLC6A4SLC6A3CHRM2 | |
| SCHEMBL4591523 | 0.80 | OPRM1 (0.47) | SLC6A4SLC6A3ADAM17OPRM1OPRL1 | |
| SCHEMBL29924430 | 0.80 | TSHR (0.49) | OPRK1SLC6A4SLC6A3KMT2AADAM17 | |
| SCHEMBL29149857 | 0.80 | TSHR (0.49) | OPRK1SLC6A4SLC6A3KMT2AADAM17 | |
| SCHEMBL15956392 | 0.79 | OPRM1 (0.46) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 | |
| SCHEMBL4942383 | 0.77 | TSHR (0.56) | SLC6A2SLC6A4SLC6A3CHRM3KMT2A | |
| SCHEMBL13887004 | 0.77 | TSHR (0.42) | OPRK1SLC6A4SLC6A3KMT2AADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6537522-B1 | Metabolically stable cocaine analogs such as 2-carbometh-oxy-3-(4-iodophenyl)-tropane; chemical intermediates for compounds having high affinities for dopamine and serotonin reuptake sites in brain | AMERSHAM PLC (GB) | 2003-03-25 | — | — | US | disclosed |
| US-5750089-A | Halogenated neuroprobe for mapping monoamine reuptake sites | NEURO IMAGING TECHNOLOGIES, LLC (US) | 1998-05-12 | — | — | US | disclosed |
| US-5698179-A | Iodinated neuroprobe for mapping monoamine reuptake sites | NEURO IMAGING TECHNOLOGIES, LLC (US) | 1997-12-16 | — | — | US | disclosed |
| EP-0703791-A4 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RES BIOMED LP (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0703791-A1 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RESEARCH BIOMEDICALS LIMITED PARTNERSHIP (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5439666-A | Central nervous system | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1995-08-08 | — | — | US | disclosed |
| WO-1995001184-A1 | AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1995-01-12 | — | — | WO | disclosed |
| US-5310912-A | Ester-substituted nortropane | RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) | 1994-05-10 | — | — | US | disclosed |