SCHEMBL7160342

SCHEMBL7160342

COC(=O)C1(c2ccc(I)c(F)c2)CC2CCC(C1)N2C

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C19 P33261 1/20 0.35
SLC6A3 Q01959 5/20 0.34
GRM5 P41594 2/20 0.34
SLC6A2 P23975 2/20 0.34
SLC6A4 P31645 2/20 0.34
CYP2D6 P10635 1/20 0.34
HRH3 Q9Y5N1 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7154360 0.88 CYP2D6 (0.38) ALDH1A1CYP1A2CYP3A4CYP2C19CYP2D6
SCHEMBL1012066 0.83 SLC6A4 (0.43) SLC6A3SLC6A2SLC6A4
SCHEMBL3656139 0.83 ALDH1A1 (0.47) ALDH1A1CYP1A2CYP3A4CYP2C19SLC6A3
SCHEMBL7157429 0.81 OPRK1 (0.46) ALDH1A1SLC6A3GRM5SLC6A2SLC6A4
SCHEMBL15956392 0.80 OPRM1 (0.46) SLC6A3SLC6A2SLC6A4
SCHEMBL4591523 0.79 OPRM1 (0.47) SLC6A3SLC6A4
SCHEMBL7568500 0.78 CYP2D6 (0.48) CYP1A2CYP2C19SLC6A3SLC6A2SLC6A4
SCHEMBL5730907 0.78 OPRM1 (0.40) CYP2D6HRH3
SCHEMBL5731263 0.78 SLC6A2 (0.36) ALDH1A1CYP1A2SLC6A3SLC6A2SLC6A4
SCHEMBL7464514 0.78 SLC6A2 (0.48) SLC6A3SLC6A2SLC6A4CYP2D6CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6537522-B1 Metabolically stable cocaine analogs such as 2-carbometh-oxy-3-(4-iodophenyl)-tropane; chemical intermediates for compounds having high affinities for dopamine and serotonin reuptake sites in brain AMERSHAM PLC (GB) 2003-03-25 US disclosed
EP-0831941-A4 IODINATED NEUROPROBES FOR MAPPING MONOAMINE REUPTAKE SITES RES BIOCHEMICALS LTD PATERNERS (US) 2002-07-03 EP disclosed
US-5750089-A Halogenated neuroprobe for mapping monoamine reuptake sites NEURO IMAGING TECHNOLOGIES, LLC (US) 1998-05-12 US disclosed
EP-0831941-A1 IODINATED NEUROPROBES FOR MAPPING MONOAMINE REUPTAKE SITES Research Biochemicals, Limited Paternership, doing business as Research biochemicals International (US) 1998-04-01 EP disclosed
US-5698179-A Iodinated neuroprobe for mapping monoamine reuptake sites NEURO IMAGING TECHNOLOGIES, LLC (US) 1997-12-16 US disclosed
WO-1996039198-A1 IODINATED NEUROPROBES FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOCHEMICALS, LIMITED PARTNERSHIP, doing business as RESEARCH BIOCHEMICALS INTERNATIONAL, A MASSACHUSETTS LIMITED PARTNERSHIP, WHOSE SOLE GENERAL PARTNER IS RBI MANAGEMENT, INC. (US) 1996-12-12 WO disclosed
EP-0703791-A4 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RES BIOMED LP (US) 1996-05-22 EP disclosed
EP-0703791-A1 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOMEDICALS LIMITED PARTNERSHIP (US) 1996-04-03 EP disclosed
US-5439666-A Central nervous system RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1995-08-08 US disclosed
WO-1995001184-A1 AN IODINATED NEUROPROBE FOR MAPPING MONOAMINE REUPTAKE SITES RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1995-01-12 WO disclosed
US-5310912-A Ester-substituted nortropane RESEARCH BIOCHEMICALS LIMITED PARTNERSHIP (US) 1994-05-10 US disclosed