Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157340 | 0.82 | NOTUM (0.48) | — | |
| SCHEMBL7248333 | 0.77 | GFER (0.46) | KIF11KCNH2 | |
| SCHEMBL7159559 | 0.76 | ALDH1A1 (0.47) | — | |
| SCHEMBL7162384 | 0.75 | GRIN2B (0.38) | KCNH2 | |
| SCHEMBL26500690 | 0.75 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL7257360 | 0.72 | DGAT1 (0.38) | — | |
| SCHEMBL1686268 | 0.71 | KIF11 (0.54) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL4880561 | 0.71 | NR1H2 (0.42) | — | |
| SCHEMBL4114372 | 0.70 | KIF11 (0.52) | KIF11CYP11B2CYP11B1 | |
| SCHEMBL7249223 | 0.70 | CYP3A4 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |