Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL642470 | 0.81 | ALDH1A1 (0.37) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL14854851 | 0.79 | ALDH1A1 (0.34) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL2669375 | 0.78 | ALDH1A1 (0.35) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL9950882 | 0.78 | TSHR (0.44) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL5520484 | 0.78 | ALDH1A1 (0.40) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL30399886 | 0.78 | SMN1; SMN2 (0.39) | ALDH1A1MAPTKDM4EHPGDSTP53 | |
| SCHEMBL15956221 | 0.77 | GABRG2 (0.46) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL30556510 | 0.77 | GABRG2 (0.46) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| Hydrochloric Acid SCHEMBL27420852 | 0.76 | ALDH1A1 (0.39) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL27956784 | 0.76 | GPR119 (0.38) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158281-C | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | ��һ��������ҩ��ʽ���� | 2004-07-21 | — | — | CN | disclosed |
| US-6541480-B2 | Controlling cytokines | SUNTORY LIMITED (JP) | 2003-04-01 | — | — | US | disclosed |
| US-20020006935-A1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | DAIICHI ASUBIO PHARMA CO., LTD. (JP) | 2002-01-17 | — | — | US | disclosed |
| US-6297248-B1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LIMITED (JP) | 2001-10-02 | — | — | US | disclosed |
| CN-1239478-A | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LTD (JP) | 1999-12-22 | — | — | CN | disclosed |
| EP-0958297-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-11-24 | — | — | EP | disclosed |
| WO-1999007704-A1 | 1-ARYL-1,8-NAPHTHYLIDIN-4-ONE DERIVATIVE AS TYPE IV PHOSPHODIESTERASE INHIBITOR | SUNTORY LIMITED (JP) | 1999-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006935-A1 | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | PDE3A, PDE5A, PDE3B | ALDH1A1 686/4885GABRG2 3864/4885GABRB3 3500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.