Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.35 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.35 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159196 | 0.78 | ALDH1A1 (0.37) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL642470 | 0.78 | ALDH1A1 (0.37) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL5520484 | 0.75 | ALDH1A1 (0.40) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| Hydrochloric Acid SCHEMBL27420852 | 0.73 | ALDH1A1 (0.39) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL27956784 | 0.73 | GPR119 (0.38) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL29470884 | 0.69 | GABRA1 (0.37) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL29470886 | 0.69 | GABRA1 (0.41) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL14854851 | 0.69 | ALDH1A1 (0.34) | ALDH1A1GABRG2GABRB3GABRA1GABRA3 | |
| SCHEMBL17253142 | 0.68 | DGAT1 (0.46) | ALDH1A1TP53MAPTALOX15HSD17B10 | |
| SCHEMBL9951442 | 0.68 | ATR (0.48) | ATRCA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010520-B1 | HETEROBICYCLIC AMIDES FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PROD INC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |