Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 19/20 | 0.67 |
| ▸ | FNTB | P49356 | 19/20 | 0.67 |
| ▸ | PGGT1B | P53609 | 17/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665146 | 0.82 | FNTA (0.73) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL5583298 | 0.80 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL7681060 | 0.80 | FNTA (0.74) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL5548038 | 0.80 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL7154862 | 0.80 | FNTA (0.73) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7592794 | 0.78 | FNTA (0.67) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7545777 | 0.78 | FNTA (0.53) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7594023 | 0.77 | FNTA (1.00) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7528653 | 0.77 | FNTA (0.63) | FNTAFNTBPGGT1BCYP11B1CYP11B2 | |
| SCHEMBL7581857 | 0.77 | FNTA (0.51) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003524618-A | — | — | 2003-08-19 | — | — | JP | claimed |
| US-20020072081-A1 | Geranylgeranyl transferase inhibitor screening assay | ENG WAI-SI (US) | 2002-06-13 | — | — | US | claimed |
| EP-1158982-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-06-12 | — | — | EP | claimed |
| US-6376496-B1 | TREATMENT OF CANCER | MERCK & CO., INC. | 2002-04-23 | — | — | US | claimed |
| EP-1158982-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000052134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | claimed |
| US-20020072081-A1 | Geranylgeranyl transferase inhibitor screening assay | ENG WAI-SI (US) | 2002-06-13 | — | — | US | disclosed |
| EP-1158982-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6376496-B1 | TREATMENT OF CANCER | MERCK & CO., INC. | 2002-04-23 | — | — | US | disclosed |
| EP-1158982-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000052134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020072081-A1 | Geranylgeranyl transferase inhibitor screening assay | GGT1, FNTA, GGPS1 | FNTA 2/4885FNTB 7/4885PGGT1B 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.