Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31332447 | 1.00 | KDM4E (0.51) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL5226658 | 0.78 | KDM4E (0.53) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL15842324 | 0.76 | KDM4E (0.56) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL1163384 | 0.76 | KDM4E (0.51) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL2448418 | 0.76 | KDM4E (0.51) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL1554147 | 0.73 | DDR2 (0.57) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL25405004 | 0.72 | MAOA (0.48) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL2016355 | 0.72 | MAOA (0.48) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 | |
| SCHEMBL11372717 | 0.72 | KDM4E (0.47) | KDM4ETHRBALDH1A1MAPTTOP2A | |
| SCHEMBL719026 | 0.72 | EYA3 (0.48) | KDM4ETHRBMAOAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871782-B1 | DIPHOSPHINES AND METAL COMPLEXES | UMICORE AG & CO KG (DE) | 2012-02-29 | — | — | EP | disclosed |
| US-7863447-B2 | Diphosphines and metal complexes | UMICORE AG & CO., KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-7837981-B2 | Methods for imaging soluble A-beta | GENERAL ELECTRIC COMPANY (US) | 2010-11-23 | — | — | US | disclosed |
| EP-1631561-B1 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GEN ELECTRIC (US) | 2010-08-18 | — | — | EP | disclosed |
| US-7727511-B2 | Agents for imaging soluble a-beta | GENERAL ELECTRIC COMPANY (US) | 2010-06-01 | — | — | US | disclosed |
| US-20090270622-A1 | Diphosphines and Metal Complexes | UMICORE AG & CO., KG (DE) | 2009-10-29 | — | — | US | disclosed |
| EP-1871782-A2 | DIPHOSPHINES AND METAL COMPLEXES | Umicore AG & Co. KG (DE) | 2008-01-02 | — | — | EP | disclosed |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | GENERAL ELECTRIC COMPANY (US) | 2007-06-21 | — | — | US | disclosed |
| WO-2006111535-A2 | DIPHOSPHINES AND METAL COMPLEXES | UMICORE AG & CO. KG (DE) | 2006-10-26 | — | — | WO | disclosed |
| EP-1631561-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004100998-A2 | COMPOSITIONS AND METHODS FOR NON-INVASIVE IMAGING OF SOLUBLE BETA-AMYLOID | GENERAL ELECTRIC COMPANY (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | GENERAL ELECTRIC COMPANY | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270622-A1 | Diphosphines and Metal Complexes | C9, AP3S1, C5 | KDM4E 3841/4885THRB 1103/4885MAOA 3519/4885 |
| US-20040223909-A1 | Compositions and methods for non-invasive imaging of soluble beta-amyloid | APP, APBA1, BACE1 | KDM4E 4841/4885THRB 2029/4885MAOA 1092/4885 |
| US-20070140960-A1 | METHODS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | KDM4E 4759/4885THRB 1258/4885MAOA 1292/4885 |
| US-20070189967-A1 | AGENTS FOR IMAGING SOLUBLE A-BETA | APBA1, APP, FABP7 | KDM4E 4807/4885THRB 1331/4885MAOA 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.