Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14261907 | 0.87 | KDM4E (0.65) | KDM4ETHRBMAPTTOP2ACA2 | |
| SCHEMBL18685767 | 0.80 | KDM4E (0.47) | KDM4ETHRBMAPTCA2CYP2C19 | |
| SCHEMBL21615029 | 0.80 | KDM4E (0.47) | KDM4ETHRBMAPTCA2CYP2C19 | |
| SCHEMBL15534884 | 0.80 | KDM4E (0.47) | KDM4ETHRBMAPTCA2CYP2C19 | |
| SCHEMBL24086761 | 0.78 | KDM4E (0.46) | KDM4EMAPTCA2CYP2C19EYA3 | |
| SCHEMBL5226658 | 0.78 | KDM4E (0.53) | KDM4ETHRBMAPTTOP2AMAOA | |
| SCHEMBL9669090 | 0.77 | KDM4E (0.55) | KDM4ETHRBMAPTCA2CYP2C19 | |
| SCHEMBL19658527 | 0.77 | KDM4E (0.55) | KDM4EMAPTCA2CYP2C19EYA3 | |
| SCHEMBL15842324 | 0.76 | KDM4E (0.56) | KDM4ETHRBMAPTTOP2ACYP2C19 | |
| SCHEMBL715966 | 0.76 | KDM4E (0.51) | KDM4ETHRBMAPTTOP2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545672-B2 | Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2026-02-10 | — | — | US | disclosed |
| US-12473283-B2 | Compounds and their use | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2025-11-18 | — | — | US | disclosed |
| EP-3880675-B1 | ANTIBIOTIC COMPOUNDS, METHODS OF MANUFACTURING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF | DEBIOPHARM INT SA (CH) | 2024-11-06 | — | — | EP | disclosed |
| US-20240317740-A1 | NOVEL COMPOUNDS AND THEIR USE | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2024-09-26 | — | — | US | disclosed |
| CN-113272302-B | Antibiotic compound, method for producing same, pharmaceutical composition containing same, and use thereof | 德彪药业国际股份公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-115151541-B | Novel compounds and uses thereof | 德彪药业国际股份公司 | 2024-06-25 | — | — | CN | disclosed |
| EP-4359079-A1 | NOVEL COMPOUNDS AND THEIR USE | Debiopharm International S.A. (CH) | 2024-05-01 | — | — | EP | disclosed |
| CN-117881679-A | Novel compounds and uses thereof | 德彪药业国际股份公司 | 2024-04-12 | — | — | CN | disclosed |
| US-20230159519-A1 | NOVEL COMPOUNDS AND THEIR USE | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2023-05-25 | — | — | US | disclosed |
| US-20230159519-A1 | NOVEL COMPOUNDS AND THEIR USE | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2023-05-25 | — | — | US | disclosed |
| US-20070191459-A1 | Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-08-16 | — | — | US | disclosed |
| US-20070191453-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION | SMITH-SWINTOSKY VIRGINIA L | 2007-08-16 | — | — | US | disclosed |
| US-20070191451-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS | SMITH-SWINTOSKY VIRGINIA L | 2007-08-16 | — | — | US | disclosed |
| US-20070191452-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | SMITH-SWINTOSKY VIRGINIA L | 2007-08-16 | — | — | US | disclosed |
| EP-1794143-A1 | NOVEL BENZO-FUSED HETEROARYL SULFAMIDE DERIVATIVES USEFUL AS ANTICONVULSANT AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-13 | — | — | EP | disclosed |
| US-20060276528-A1 | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents | ABDEL-MAGID AHMED F | 2006-12-07 | — | — | US | disclosed |
| US-20060270856-A1 | Process for preparation of sulfamide derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2006-11-30 | — | — | US | disclosed |
| WO-2006127184-A1 | PROCESS FOR PREPARATION OF SULFAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006023861-A1 | NOVEL BENZO-FUSED HETEROARYL SULFAMIDE DERIVATIVES USEFUL AS ANTICONVULSANT AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-02 | — | — | WO | disclosed |
| US-20060047001-A1 | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents | JANSSEN PHARMACAEUTICA N.V. (BE) | 2006-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159519-A1 | NOVEL COMPOUNDS AND THEIR USE | LSS, PGLS, LDHB | KDM4E 175/4885THRB 2077/4885MAPT 1933/4885 |
| US-20060276528-A1 | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents | GABRA5, SULT2A1, SYNGR2 | KDM4E 1073/4885THRB 3953/4885MAPT 701/4885 |
| US-20070191451-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS | NLN, CTSA, SMN1; SMN2 | KDM4E 3579/4885THRB 3293/4885MAPT 464/4885 |
| US-20060047001-A1 | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents | GABRE, GABRB2, GABRA2 | KDM4E 1493/4885THRB 3723/4885MAPT 1366/4885 |
| US-20240317740-A1 | NOVEL COMPOUNDS AND THEIR USE | PGLS, LSS, LAS1L | KDM4E 95/4885THRB 3216/4885MAPT 1616/4885 |
| US-20070191459-A1 | Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels | LIPC, GPR119, APOB | KDM4E 1961/4885THRB 1543/4885MAPT 4122/4885 |
| US-12545672-B2 | Antibiotic compounds, methods of manufacturing the same, pharmaceutical compositions containing the same and uses thereof | MRPL21, EMG1, RRS1 | KDM4E 1019/4885THRB 2131/4885MAPT 4422/4885 |
| US-20070191452-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | OPRL1, SULT2A1, OPRK1 | KDM4E 3537/4885THRB 2785/4885MAPT 3691/4885 |
| US-12473283-B2 | Compounds and their use | LSS, PGLS, LDHB | KDM4E 111/4885THRB 2353/4885MAPT 1798/4885 |
| US-20060270856-A1 | Process for preparation of sulfamide derivatives | STS, SULT2A1, SULT1A1 | KDM4E 2544/4885THRB 2815/4885MAPT 4094/4885 |
| US-20070191453-A1 | USE OF BENZO-HETEROARYL SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION | SULT2A1, SULT1A1, STS | KDM4E 1979/4885THRB 1008/4885MAPT 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.