Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1231511 | 0.90 | MTNR1A (0.58) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| Hydroxyamine SCHEMBL7159763 | 0.86 | MTNR1A (0.57) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1234076 | 0.85 | HDAC1 (0.69) | MTNR1AMEN1KMT2ALMNAHDAC1 | |
| SCHEMBL7974076 | 0.84 | LMNA (0.61) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL9797755 | 0.83 | LMNA (0.63) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL18229460 | 0.82 | MTNR1A (0.70) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16596182 | 0.82 | MTNR1A (0.70) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6791700 | 0.82 | MTNR1A (0.55) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7970603 | 0.82 | LMNA (0.61) | MTNR1AALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7976825 | 0.81 | SMN1; SMN2 (0.71) | MTNR1AALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335898-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | Prolifix Limited (GB) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002026696-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN AMIDE LINKAGE AS HDAC INHIBITORS | PROLIFIX LIMITED (GB) | 2002-04-04 | — | — | WO | disclosed |