Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TERT | O14746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18229460 | 1.00 | MTNR1A (0.70) | MTNR1ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL3667317 | 0.99 | MTNR1A (0.68) | MTNR1ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL7974076 | 0.90 | LMNA (0.61) | MTNR1ALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL10272692 | 0.89 | MTNR1A (0.64) | MTNR1ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL27099051 | 0.88 | MTNR1A (0.82) | MTNR1ALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL7970603 | 0.87 | LMNA (0.61) | MTNR1ALMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL7976825 | 0.86 | SMN1; SMN2 (0.71) | MTNR1ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL27099048 | 0.86 | MTNR1A (0.80) | MTNR1ALMNAALDH1A1HPGDKMT2A | |
| SCHEMBL9797755 | 0.86 | LMNA (0.63) | LMNAALDH1A1KMT2AMEN1GAA | |
| SCHEMBL1231511 | 0.85 | MTNR1A (0.58) | MTNR1ALMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751851-B2 | Molecules and compositions that inhibit gram negative bacteria and their uses | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2017-09-05 | — | — | US | disclosed |
| US-20160368892-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2015042363-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368892-A1 | MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES | BLVRB, PGLS, GRHPR | MTNR1A 1405/4885LMNA 4678/4885ALDH1A1 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.