SCHEMBL715992

SCHEMBL715992

COc1ccc(C(OC(Br)CO)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 11/20 0.50
KCNH2 Q12809 1/20 0.43
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LTA4H P09960 1/20 0.39
CA4 P22748 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20371123 0.79 KIF11 (0.51) KIF11KCNH2LMNAHTTSMN1; SMN2
SCHEMBL715991 0.79 AGTR1 (0.38) KIF11LMNAHTTSMN1; SMN2CA4
SCHEMBL20371105 0.78 KIF11 (0.53) KIF11KCNH2LMNAHTTSMN1; SMN2
SCHEMBL17928455 0.78 KIF11 (0.46) KIF11KCNH2LMNAHTTSMN1; SMN2
SCHEMBL21562153 0.77 CA4 (0.46) KIF11KCNH2LTA4HCA4
SCHEMBL17173364 0.77 CA4 (0.46) KIF11KCNH2LTA4HCA4
SCHEMBL8454432 0.77 KIF11 (0.45) KIF11KCNH2LTA4HCA4
SCHEMBL10495868 0.76 KIF11 (0.45) KIF11KCNH2HTT
SCHEMBL16214813 0.76 KIF11 (0.50) KIF11KCNH2
SCHEMBL3487683 0.76 KIF11 (0.50) KIF11KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8436138-B2 Binder for C-reactive protein MODPRO AB (SE) 2013-05-07 US disclosed
US-20120053124-A1 BINDER FOR C-REACTIVE PROTEIN MODPRO AB (SE) 2012-03-01 US disclosed
US-8017347-B2 Binder for C-reactive protein MODPRO AB (SE) 2011-09-13 US disclosed
US-20090305298-A1 Binder for C-Reactive Protein MODPRO AB (SE) 2009-12-10 US disclosed
EP-2007801-A1 BINDER FOR C-REACTIVE PROTEIN Modpro AB (SE) 2008-12-31 EP disclosed
WO-2007117215-A1 BINDER FOR C-REACTIVE PROTEIN MODPRO AB (SE) 2007-10-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090305298-A1 Binder for C-Reactive Protein C1QBP, RBP1, MYCBP KIF11 4602/4885KCNH2 4495/4885LMNA 2495/4885
US-20120053124-A1 BINDER FOR C-REACTIVE PROTEIN C1QBP, RBP1, MYCBP KIF11 4602/4885KCNH2 4495/4885LMNA 2495/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.