Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.30 |
| ▸ | MAPT | P10636 | 5/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040317 | 0.79 | NOTUM (0.34) | NOTUMTDP1MGLLMAOBHCAR1 | |
| SCHEMBL4716988 | 0.79 | ENPP2 (0.47) | KDM4EALOX15TDP1MGLLALDH1A1 | |
| SCHEMBL17626275 | 0.79 | NOTUM (0.47) | F2NOTUMMGLLADRB1MAPT | |
| SCHEMBL1900336 | 0.75 | KDM4E (0.37) | ELANENOTUMKDM4ETSHRALDH1A1 | |
| SCHEMBL7124670 | 0.74 | KMT2A (0.40) | L3MBTL1ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL7160454 | 0.71 | ALKBH5 (0.39) | NOTUM | |
| SCHEMBL6518759 | 0.70 | CYP2C9 (0.58) | F2ELANECTSGCMA1CTRC | |
| SCHEMBL5535953 | 0.65 | ELANE (0.38) | F2ELANECTSGCMA1CTRC | |
| SCHEMBL171705 | 0.64 | LMNA (0.64) | NOTUMALOX15TSHRTDP1CYP1A2 | |
| SCHEMBL1366622 | 0.62 | L3MBTL1 (0.56) | F2ELANECTSGCMA1CTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002060877-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-08 | — | — | WO | disclosed |