Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178557 | 0.78 | PTGS2 (0.53) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| Ethylene SCHEMBL7162487 | 0.78 | PTGS2 (0.55) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL29385521 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL2464202 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL10942403 | 0.73 | PTGS2 (0.62) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL30957305 | 0.72 | CASP1 (0.50) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL21505155 | 0.72 | CASP1 (0.50) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL11181698 | 0.70 | CASP1 (0.45) | PTGS2CASP1CASP7HSD17B10ALDH1A1 | |
| SCHEMBL576377 | 0.70 | ALDH1A1 (0.46) | PTGS2PTGS1ALDH1A1MAPK14 | |
| SCHEMBL30452220 | 0.70 | ALDH1A1 (0.46) | PTGS2PTGS1ALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE38103-E1 | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA & CO. (CA) | 2003-04-29 | — | — | US | disclosed |
| EP-0673366-B1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC (CA) | 1998-10-14 | — | — | EP | disclosed |
| US-5604260-A | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 | MERCK FROSST CANADA INC. (CA) | 1997-02-18 | — | — | US | disclosed |
| EP-0673366-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013635-A1 | 5-METHANESULFONAMIDO-1-INDANONES AS AN INHIBITOR OF CYCLOOXYGENASE-2 | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |