Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9406800 | 0.79 | — | — | |
| SCHEMBL10464804 | 0.79 | — | — | |
| SCHEMBL509071 | 0.75 | — | — | |
| SCHEMBL16447412 | 0.72 | BRD4 (0.32) | — | |
| Methane SCHEMBL5905793 | 0.68 | — | — | |
| SCHEMBL3408459 | 0.65 | — | — | |
| SCHEMBL4551233 | 0.65 | — | — | |
| SCHEMBL2288254 | 0.65 | — | — | |
| SCHEMBL11771368 | 0.65 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL29662768 | 0.64 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124668-B2 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2012-02-28 | — | — | US | claimed |
| US-20060142410-A1 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2006-06-29 | — | — | US | claimed |
| EP-1582910-A1 | HIGHLY SAFE SILICONE-CONTAINING MATERIAL FOR OCULAR LENS AND PROCESS FOR PRODUCING THE SAME | MENICON CO., LTD. (JP) | 2005-10-05 | — | — | EP | claimed |
| EP-2432821-B1 | ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS | NOVARTIS AG (CH) | 2017-08-30 | — | — | EP | disclosed |
| US-9066981-B2 | Actinically-crosslinkable siloxane-containing copolymers | NOVARTIS AG (CH) | 2015-06-30 | — | — | US | disclosed |
| US-20140100291-A1 | Actinically-Crosslinkable Siloxane-Containing Copolymers | NOVARTIS AG (CH) | 2014-04-10 | — | — | US | disclosed |
| US-8642712-B2 | Actinically-crosslinkable siloxane-containing copolymers | NOVARTIS AG (CH) | 2014-02-04 | — | — | US | disclosed |
| EP-2180366-B1 | SILICONE-CONTAINING OCULAR LENS MATERIAL WITH HIGH SAFETY AND PREPARING METHOD THEREOF | MENICON CO LTD (JP) | 2013-09-25 | — | — | EP | disclosed |
| EP-2432821-A1 | ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS | Novartis AG (CH) | 2012-03-28 | — | — | EP | disclosed |
| US-8124668-B2 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| WO-2010135481-A1 | ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS | NOVARTIS AG (CH) | 2010-11-25 | — | — | WO | disclosed |
| US-20100298446-A1 | ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS | ALCON INC. (CH) | 2010-11-25 | — | — | US | disclosed |
| EP-2180366-A1 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2010-04-28 | — | — | EP | disclosed |
| US-20060142410-A1 | Silicone-containing ocular lens material with high safety and preparing method thereof | MENICON CO., LTD. (JP) | 2006-06-29 | — | — | US | disclosed |
| EP-1582910-A1 | HIGHLY SAFE SILICONE-CONTAINING MATERIAL FOR OCULAR LENS AND PROCESS FOR PRODUCING THE SAME | MENICON CO., LTD. (JP) | 2005-10-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298446-A1 | ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS | ATRIP, ATR, MACF1 | ALDH1A1 1684/4885L3MBTL1 2200/4885SMN1; SMN2 4503/4885 |
| US-20140100291-A1 | Actinically-Crosslinkable Siloxane-Containing Copolymers | ATRIP, ATR, MACF1 | ALDH1A1 1684/4885L3MBTL1 2200/4885SMN1; SMN2 4503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.