⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3292484 | 0.80 | L3MBTL1 (0.35) | — | |
| SCHEMBL17930928 | 0.71 | — | — | |
| SCHEMBL12326733 | 0.71 | — | — | |
| SCHEMBL10464804 | 0.71 | — | — | |
| SCHEMBL9406800 | 0.71 | — | — | |
| SCHEMBL172654 | 0.69 | PNMT (0.61) | — | |
| SCHEMBL14452925 | 0.68 | BRD4 (0.33) | — | |
| SCHEMBL6839636 | 0.66 | — | — | |
| SCHEMBL716292 | 0.65 | ALDH1A1 (0.38) | — | |
| SCHEMBL11817088 | 0.64 | L3MBTL1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152713-B1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARM INC (US) | 2011-09-07 | — | — | EP | disclosed |
| US-7977368-B2 | Pyrazolopyrrolidines as inhibitors of gamma secretase | ELAN PHARMACEUTICALS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2152713-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| US-20090099235-A1 | Pyrazolopyrrolidines as Inhibitors of Gamma Secretase | ELAN PHARMACEUTICALS, INC. | 2009-04-16 | — | — | US | disclosed |
| WO-2008147800-A1 | PYRAZOLOPYRROLIDINES AS INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |