Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164728 | 0.85 | SIRT2 (0.42) | SIRT2ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL7247143 | 0.70 | ALDH1A1 (0.46) | ALDH1A1GAA | |
| SCHEMBL6412396 | 0.69 | SIRT2 (0.33) | SIRT2 | |
| SCHEMBL8003684 | 0.68 | DRD2 (0.34) | ALDH1A1KDM4ELMNAGAAKMT2A | |
| SCHEMBL7163976 | 0.67 | MTNR1A (0.43) | ALDH1A1LMNAGAAHTT | |
| SCHEMBL3976810 | 0.63 | SIRT2 (0.45) | SIRT2 | |
| SCHEMBL487112 | 0.63 | TRPV1 (0.44) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL1041048 | 0.62 | SIRT2 (0.49) | SIRT2 | |
| SCHEMBL7084063 | 0.62 | SIRT2 (0.43) | SIRT2ALDH1A1KDM4ELMNA | |
| SCHEMBL7080830 | 0.61 | SIRT2 (0.44) | SIRT2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |