SCHEMBL716498

SCHEMBL716498

N[C@@H]1[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]1n1ccc(=O)[nH]c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 15/20 1.00
P2RY4 P51582 10/20 1.00
P2RY6 Q15077 8/20 0.96
P2RY14 Q15391 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14396709 1.00 P2RY2 (1.00) P2RY2P2RY4P2RY6P2RY14
SCHEMBL716499 1.00 P2RY2 (1.00) P2RY2P2RY4P2RY6P2RY14
SCHEMBL5484468 0.94 P2RY2 (0.88) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL2778525 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL76683 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL24414746 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL12671699 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL14976686 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL14406726 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14
Uridine Triphosphate SCHEMBL107380 0.91 P2RY2 (0.94) P2RY2P2RY4P2RY6P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 771 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE TRANSLATE BIO INC (US) 2024-12-19 US claimed
US-11998601-B2 Messenger RNA therapy for treatment of articular disease TRANSLATE BIO, INC. (US) 2024-06-04 US claimed
US-20220145295-A1 ENZYMATIC RNA SYNTHESIS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-05-12 US claimed
US-20210052706-A1 COMPOSITIONS AND METHODS FOR FACILITATING DELIVERY OF SYNTHETIC NUCLEIC ACIDS TO CELLS TRANSLATE BIO MA, INC. (US) 2021-02-25 US claimed
EP-3737424-A1 COMPOSITIONS AND METHODS FOR FACILITATING DELIVERY OF SYNTHETIC NUCLEIC ACIDS TO CELLS Translate Bio MA, Inc. (US) 2020-11-18 EP claimed
US-20190175756-A1 METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE II WITH mRNA ENCODING ACID GLUCOSIDASE ALPHA (GAA) CUREVAC AG (DE) 2019-06-13 US claimed
US-20190175757-A1 METHODS OF TREATING A SUBJECT HAVING FRIEDREICH'S ATAXIA WITH mRNA ENCODING FRATAXIN CUREVAC AG (DE) 2019-06-13 US claimed
US-20190175759-A1 METHODS OF TREATING A SUBJECT HAVING PROPIONIC ACIDEMIA WITH mRNA ENCODING PROPIONYL-COA CARBOXYLASE, SUBUNIT ALPHA AND/OR BETA (PCCA AND/OR PCCB) CUREVAC AG (DE) 2019-06-13 US claimed
US-20190175758-A1 METHODS OF TREATING A SUBJECT HAVING CITRULLINEMIA WITH mRNA ENCODING ARGININOSUCCINATE SYNTHASE (ASS) CUREVAC AG (DE) 2019-06-13 US claimed
US-20190175760-A1 METHODS OF TREATING A SUBJECT HAVING GLYCOGEN STORAGE DISEASE WITH mRNA ENCODING GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT (G6PC) CUREVAC AG (DE) 2019-06-13 US claimed
EP-3033424-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA Rana Therapeutics, Inc. (US) 2016-06-22 EP claimed
EP-2978402-A1 STABILIZED POLYRIBONUCLEOTIDE CODING FOR AN ELASTIC FIBROUS PROTEIN Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) 2016-02-03 EP claimed
WO-2015023975-A1 COMPOSITIONS AND METHODS FOR MODULATING RNA RANA THERAPEUTICS, INC. (US) 2015-02-19 WO claimed
WO-2014154844-A1 STABILIZED POLYRIBONUCLEOTIDE CODING FOR AN ELASTIC FIBROUS PROTEIN EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) 2014-10-02 WO claimed
US-20120195936-A1 RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION ETHRIS GMBH (DE) 2012-08-02 US claimed
EP-2235177-B1 METHOD FOR ENZYMATIC SYNTHESIS OF CHEMICALLY MODIFIED RNA RIBOXX GMBH (DE) 2012-07-18 EP claimed
EP-0724647-A4 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME GILEAD SCIENCES INC (US) 2003-09-17 EP claimed
US-6184364-B1 DEHYDRATING URIDINE TO FORM 2,2'-ANHYDROURIDINE, CONVERTING TO UNPROTECTED 2'-AZIDO-2'-DEOXYURIDINE, IODINATING TO FORM 5-IODO-2'-AZIDO, 2'-DEOXYURIDINE, THEN REDUCING TO 5-IODO, 2'-AMINO-2'-DEOXYURIDINE; SELEX LIGANDS NEXSTAR PHARMACEUTICALS, INC. 2001-02-06 US claimed
EP-0724647-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NeXstar Pharmaceuticals, Inc. (US) 1996-08-07 EP claimed
WO-1995007364-A1 NUCLEIC ACID LIGANDS AND IMPROVED METHODS FOR PRODUCING THE SAME NEXSTAR PHARMACEUTICALS, INC. (US) 1995-03-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY4 4107/4885P2RY6 3298/4885
US-20210052706-A1 COMPOSITIONS AND METHODS FOR FACILITATING DELIVERY OF SYNTHETIC NUCLEIC ACIDS TO CELLS NSUN3, RNGTT, CSGALNACT1 P2RY2 4737/4885P2RY4 4781/4885P2RY6 4211/4885
US-11998601-B2 Messenger RNA therapy for treatment of articular disease NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY4 4107/4885P2RY6 3298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.