Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.49 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7162166 | 0.99 | THRA (0.47) | THRATHRBNR5A1TP53TSHR | |
| SCHEMBL7165354 | 0.86 | L3MBTL1 (0.54) | THRATHRBNR5A1TSHRNPC1 | |
| SCHEMBL3363351 | 0.84 | LSS (0.61) | LSS | |
| SCHEMBL7173347 | 0.82 | KDM4E (0.43) | THRATHRBLTA4HLSSMAOB | |
| SCHEMBL3368284 | 0.82 | LSS (0.59) | LSS | |
| SCHEMBL7166190 | 0.79 | S1PR1 (0.48) | THRATHRBTSHRLTA4HLMNA | |
| SCHEMBL28426813 | 0.78 | THRA (0.48) | THRATHRBNR5A1TP53TSHR | |
| SCHEMBL3364497 | 0.78 | LSS (0.51) | TSHRLSS | |
| SCHEMBL3368340 | 0.78 | FFAR1 (0.53) | LTA4HLSS | |
| SCHEMBL3368626 | 0.78 | PGR (0.53) | TP53TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |